Tuesday 9 July 2013

Dogs to sniff out cancers

About 1,660,290 new cancer cases are expected to be diagnosed in 2013, and about 580,350 Americans are projected to die of cancer, almost 1,600 people a day. In 2010, a total of 157,250 people died in UK due to cancer related diseases. Cancer remains the second most common cause of death, accounting for nearly 25% of all deaths in both countries.


A number of dogs are undergoing training to get skills of detecting cancers. The most recent type of cancer to be detected by sniffer dogs is bladder cancer
In 2001, a Labrador retriever sniffed out bowel cancer in breath and stool samples during a study in Japan. The observation was however taken lightly assuming that it was just an isolated case.
In 2004, the Medical Detection Dogs a charity that works with researchers, NHS Trusts and universities to train specialist dogs to detect the odour of human disease was established. The consortium was formed after a letter from Dr John Church to medical journal. The Lancet claimed dogs could detect bladder cancer. According to Dr Guest the chief executive of the Medical Detection Dogs, stories of dogs finding their owners' cancer had been reported for a while. They started to wonder that if dogs were finding it by chance then perhaps they could actually train dogs to do this reliably.
In 2012, a woman discovered she had a cancerous tumour in her breast after her dog started sniffing and pawing at it. Sharon Rawlinson ignored her Cavalier King Charles Spaniel for months, but went for tests after Penny stepped on her chest, causing pain. Mrs Rawlinson, from Newark, then examined herself and found a lump.
Recently, Medical Detection Dogs chief executive Dr Claire Guest was training dogs to detect other cancers, when she said one of them warned her. She was subsequently found to have an early stage breast tumour. Nowadays, Dr Guest trains dogs to recognise the cancer from a breath sample, hoping that an electronic nose can be developed.

The Medical Detection Dogs charity started to work with dogs and can now accurately pick out cancer samples from control samples, but research has been mainly limited to bladder and prostate cancer.
Other cancers have been brought on board for detection including; breast cancer from a breath tube. This was after the dog Dr Guest was training to detect other cancers started to warn her. "I was a bit bemused as to what she was doing, but I was subsequently found to have a very early stage breast tumour," she said.
"It was very deep and had my dog Daisy not warned me, I was told it could have been very serious and life-threatening because by the time I felt the lump it would have been very advanced."
Now in remission, the scientist has joined forces with her surgeon and other cancer specialists to search for the clinical proof that breast cancer can be "sniffed out". In particular, they are looking to see if dogs can recognise it accurately and reliably from a breath test.
"There is a huge amount of potential for this work, not only in finding out where cancer is present but also in the development of an electronic nose in the future," said Dr Guest.
"A dog is in fact a very, very specialist pattern recognition bi-sensor - but he has got a waggy tail. "He can tell us when something is there and when it's not and how quickly it disappears [when a sample is in contact with the air] and they can tell us how difficult it is to find.
"If we can find out how the dog is doing it then we can make machines in the future that could screen our breath and our urine for cancer volatiles.
This research is at a very early stage and the next step will be a clinical trial with samples from local hospitals. "We need to find out how reliably dogs can indicate this and also if they can reliably indicate early grade and stage, because that would be the key for survival," said Dr Guest.
The hope is this research "has the potential to save thousands of lives".


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